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The Sensitivity and Specificity of Suggested Diagnostic Biomarkers/Algorithms
| Specificity (%) to: | |||||||
|---|---|---|---|---|---|---|---|
| Facilitated diagnosis | Biomarker/algorithm | Sensitivity (%) | Ctrl | HCV | PSC | PBC | AIH |
| PSC, PBC, or AIH | E3>28 | 79, 84, or 100 | 98 | 93 | NA | NA | NA |
| PSC | E3>28+E1/E3>15+CCL22>2800 | 67 | 98 | 98 | NA | 94 | 92 |
| PSC | E3>25+E1/E3>15+CCL22>2800 | 72 | 97 | 94 | NA | 94 | 92 |
| PSC | E3>23+E1/E3>15+CCL22>2800 | 76 | 94 | 94 | NA | 90 | 92 |
| AIH | E3>25+E1/E3<15+CCL22>1870+IL-15>2.4 | 60 | 100 | 100 | 100 | 90 | NA |
Ctrl, healthy controls; NA, not applicable.
