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. 2014 Apr 1;20(10):1646–1654. doi: 10.1089/ars.2013.5482

FIG. 4.

FIG. 4.

The effect of sirtuin gene expression on life span. This is the graphical summary of data obtained from increased or decreased sirtuin expression in Caenorhabditis elegans. Overexpression of sirtuin genes results in increases in the life span (arrow A), whereas underexpression of these genes shortened the life span (arrow B). The time of the inflection point (circle) is shifted, but the general shape of the survival curve remains unchanged.