FIG. 7.

SIRT3 mitochondrial deacetylation targets. Data suggest that the MnSOD enzymatic activity is directed by acetylation of lysine 122 following fasting or exposure to radiation through the activation of Sirt3. It has also been proposed that the SIRT3 activity is directed and subsequently regulated by changes in cellular NAD+/NADH ratios and this alters the SIRT3 enzymatic activity. After activation, SIRT3 has also been shown to regulate the activity of other mitochondrial proteins, including acetyl-CoA synthetase (AceCS2), glutamate dehydrogenase (GDH), long-chain acyl-CoA dehydrogenase (LCAD), and isocitrate dehydrogenase (IDH2).