Table 10.
The composition of liver samples after four weeks of DON feeding and after the recovery phase of two weeks; n = 6; mean ± SEM; means with the same letter (a and/or b) are not significantly different from each other (significance tested with Mann-Whitney U-tests, p < 0.05).
| Liver Composition | Basal Feed | Low DON | Medium DON | High DON |
|---|---|---|---|---|
| DON-treated: | ||||
| Dry matter (% wet matter) | 25.9 ± 0.8 | 22.9 ± 2.2 | 25.6 ± 0.8 | 27.0 ± 1.4 |
| Total lipids (% wet matter) | 15.0 ± 1.3 | 14.5 ± 1.2 | 16.2 ± 1.7 | 17.3 ± 1.7 |
| Free glucose (mM g−1 wet matter) | 1.16 ± 0.27 | 0.87 ± 0.14 | 1.19 ± 0.08 | 0.91 ± 0.19 |
| Lactate (mM g−1 wet matter) | 1.75 ± 0.48 | 3.05 ± 1.29 | 3.77 ± 2.03 | 3.56 ± 1.87 |
| AST (U mg protein−1) | 90.3 ± 18.2 | 60.2 ± 20.5 | 81.7 ± 8.2 | 89.1 ± 16.6 |
| ALT (U mg protein−1) | 1.43 ± 0.14 a | 2.61 ± 0.98 a,b | 2.95 ± 0.51 b | 2.73 ± 0.49 a,b |
| Ascorbate (μM g−1 wet matter) | 81.7 ± 15.7 | 63.5 ± 8.3 | 71.5 ± 14.8 | 54.3 ± 8.8 |
| Recovery: | ||||
| Dry matter (% wet matter) | 25.1 ± 0.5 a | 28.9 ± 1.4 a | 27.5 ± 1.8 a,b | 25.8 ± 1.7 a,b |
| Total lipids (% wet matter) | 17.7 ± 1.2 a | 19.2 ± 1.3 a,b | 18.7 ± 0.8 a,b | 23.6 ± 4.1 b |
| Free glucose (mM g−1 wet matter) | 0.73 ± 0.10 | 0.96 ± 0.17 | 0.91 ± 0.12 | 0.99 ± 0.21 |
| Lactate (mM g−1 wet matter) | 1.36 ± 0.35 a | 3.74 ± 1.13 a,b | 6.48 ± 2.02 b | 2.85 ± 0.80 a,b |
| AST (U mg protein−1) | 98.5 ± 22.1 | 96.5± 27.5 | 81.7 ± 8.2 | 99.7 ± 10.8 |
| ALT (U mg protein−1) | 2.47 ± 0.23 | 2.88 ± 0.22 | 2.79 ± 0.11 | 3.03 ± 0.26 |
| Ascorbate (μM g−1 wet matter) | 51.8 ± 6.5 | 58.8 ± 7.0 | 64.9 ± 7.5 | 62.2 ± 7.6 |