Table 3.
Studies reporting the interobserver variability in TB, GTV, CTV and PTV delineation after breast-conserving surgery
| Number of patients | Number of observers | Studied target volume | Volume (cc)¶ | Method | Outcome¶ | ||
|---|---|---|---|---|---|---|---|
| a) CT |
Struikmans 2005 [4] |
18 |
5 |
TB |
Mean 20 (6.4-75.8) |
CIpairs |
Mean 0.56 (0.39-0.74) |
| |
Petersen 2007 [5] |
30 |
3 |
TB |
Mean 48.7 (10.3-189.3) |
CIcommon |
Mean 0.61 (0.27-0.84) |
| dCOM |
0.5-1.1* (SD 0. 5–1.8) |
||||||
| |
Hurkmans 2009 [6] |
10 |
4 |
TB |
40 |
CIcommon |
Mean 0.31 (range 0.11 – 0.52) |
| |
Coles 2009 [7] |
12 |
2 |
TB |
29.0 (SD 28.5) |
dCOM |
Median 3 (range 1–9) |
| 18.7 (8–116) | |||||||
| |
Jolicoeur 2011 [8] |
66 |
3 |
TB |
13.7 |
CIcommon |
Mean 0.66 |
| |
Giezen 2012 [9] |
15 |
4 |
TB |
27 (SD 25) |
CIgen |
0.52 (SD 0.21) |
| dCOM |
4 (SD 3) |
||||||
| |
Van Mourik 2010 [10] |
8 |
13 |
CTV |
n.a. |
CIpairs |
0.61# (range 0.35 – 0.79) |
| dCOM |
7.25 (2.73 – 26.87) |
||||||
| |
Boersma 2012 [11] |
26 |
5 |
CTV |
41.9 (SD 34) |
CIpairs |
0.36 (SD 0.21) |
| dCOM |
11 (SD 8) |
||||||
| |
Van den Assem 2012 [12] |
19 |
3 |
CTV |
37.6 |
CIpairs |
Mean 0.59 |
| dCOM |
Mean 5.5 |
||||||
| |
Landis 2007 [13] |
29 |
4 |
PTV |
202 (65–492) |
CIpairs |
0.76 (0.52-0.92) |
| dCOM |
2.5 (0. 7–11.5) |
||||||
| b) MRI |
Jolicoeur 2011 [8] |
66 |
3 |
TB |
10.1 |
CIcommon |
Mean 0.96 |
| |
Giezen 2012 [9] |
15 |
4 |
TB |
27 (SD 26) |
CIgen |
0.32 (0.25) |
| dCOM |
11(SD 10) |
||||||
| c) CT + additional preop CT |
Boersma 2012 [11] |
26 |
5 |
CTV |
36 (SD 31) |
CIpairs |
0.36 (SD 0.19) |
| dCOM |
10 (SD 7) |
||||||
| |
Van den Assem 2012 [12] |
19 |
3 |
CTV |
34.7 |
CIpairs |
Mean 0.68 |
| dCOM |
Mean 2.9 |
||||||
| d) Preop CT |
Boersma 2012 [11] + vd Leij 2012 [18] (same dataset) |
26 |
5 |
GTV |
0.99 |
CIpairs |
0.45 (SD 0.22) |
| dCOM |
4.3 (SD 7.6) |
||||||
| CTV |
37.5 |
CIpairs |
Mean 0.77 |
||||
| dCOM |
Mean 4.4 |
||||||
| |
This study (excluding 2 misdelineations) |
12 |
4 |
GTV |
2.1 |
CIpairs |
0.56 (0.11 – 0.83) |
| dCOM |
1.1 (0.3 – 12.8) |
||||||
| CTV |
48.1 |
CIpairs |
0.82 (0.39 – 0.93) |
||||
| 1.4 (0.3 – 13.6) | |||||||
| e) Preop MRI | This study (excluding 2 misdelineations) | 12 | 4 | GTV |
2.7 |
CIpairs |
0.61 0.37 – 0.78) |
| dCOM |
1.2 (0.3 – 3.6) |
||||||
| CTV | 59.0 | CIpairs |
0.84 (0.47 – 0.93) |
||||
| dCOM | 1.8 (0.1 – 4.8) |
*Range of the mean dCOM in x-y and z-direction and range in SD.
#CI values of one observer with all twelve observers were averaged.
¶Volume, CI and dCOM: reflected in median (range) or mean ± SD, unless stated differently.
TB Tumor Bed volume, GTV Gross Tumor Volume, CTV Clinical Target Volume, PTV Planning Target Volume.
CI Conformity Index, method of analysis (common, pairs, general) as described by Van Kouwenhoven et al. [27].
dCOM Distance between the Centers of Mass (mm).