Table 1.
Use of ablative therapies to treat cystic and solid premalignant lesions of the pancreas
| Author | Premalignant lesion | n | Treatment | Median area of ablation, mm (range) | Outcome | Complications |
| Gan et al[46] | Cystic tumours of the pancreas | 25 | EUS guided ethanol lavage | 19.4 (6-30) | Complete resolution 35% | None |
| Oh et al[73] | Cystic tumours of the pancreas | 14 | EUS guided ethanol lavage + paclitaxel | 25.5 (17-52) | Complete resolution in 79% | Acute pancreatitis (n = 1) Hyperamylasaemia (n = 6) Abdominal pain (n = 1) |
| Oh et al[74] | Cystic tumours of the pancreas | 10 | EUS guided ethanol lavage + paclitaxel | 29.5 (20-68) | Complete resolution in 60% | Mild pancreatitis (n = 1) |
| DeWitt et al[75] | Cystic tumours of the pancreas | 42 | Randomised double blind study: Saline vs ethanol | 22.4 (10-58) | Complete resolution in 33% | Abdominal pain at 7 d (n = 5) Pancreatitis (n = 1) Acystic bleeding (n = 1) |
| Oh et al[47] | Cystic tumours of the pancreas | 52 | EUS guided ethanol lavage + paclitaxel | 31.8 (17-68) | Complete resolution in 62% | Fever (1/52) Mild abdominal discomfort (1/52) Mild pancreatitis (1/52) Splenic vein obliteration (1/52) |
| Levy et al[76] | PNET | 8 | EUS guided ethanol lavage (5 patients) and intra-operative ultrasound guided (IOUS) ethanol lavage (3 patients) | 16.6 (8-21) | Hypoglycemia symptoms disappeared 5/8 and significantly improved 3/8 | EUS guided: No complications. IOUS-guided ethanol injection: Minor peritumoral bleeding (1/3), pseudocyst (1/3), pancreatitis (1/3) |
| Pai et al[21] | Cystic tumours of the pancreas + neuroendocrine tumours | 8 | EUS guided RFA | Mean size pre RFA, 38.8 mm vs mean size post RFA, 20 mm | Complete ablation in 25% (2/8) | 2/8 patients had mild abdominal pain that resolved in 3 d |
RFA: Radiofrequency ablation; EUS: Endoscopic ultrasound; PNET: Pancreatic neuroendocrine tumour.