Table II.
Mean myofibre diameter, centro-nuclear myofibres, fibrosis, Pax7+ myofibres, vWF per myofibre and CD56+ myofibres of muscle biopsies of the injured biceps muscle before MNC injection and at three months follow-up
| Group | |||||
|---|---|---|---|---|---|
| Mean (sd) biceps histology | A (n = 3) | B (n = 3) | C (n = 3) | p-value* | Total (n = 9) |
| Myofibre diameter (µm) | |||||
| 0 months | 254 (68) | 173 (46) | 171 (12) | 193 (53) | |
| 3 months | 392 (165) | 391 (44) | 274 (71) | 347 (98) | |
| Mean difference | +138 | +218 | +103 | 0.39 | 0.007† |
| Centro-nuclear myofibres (%) | |||||
| 0 months | 5.1 (2.5) | 2.1 (1.5) | 2.6 (1.7) | 3.1 (2.0) | |
| 3 months | 2.7 (0.8) | 6.0 (3.1) | 3.4 (1.9) | 4.2 (2.5) | |
| Mean difference | -2.4 | +3.9 | +0.8 | 0.01 | 0.30† |
| Fibrosis (%) | |||||
| 0 months | 18 (2) | 31 (2) | 23 (4) | 25 (6) | |
| 3 months | 17 (15) | 9 (4) | 12 (2) | 12 (7) | |
| Mean difference | -1 | -22 | -11 | 0.06 | 0.01† |
| Pax7+ myofibres (%) | |||||
| 0 months | 17 (4) | 6 (3) | 14 (6) | 12 (6) | |
| 3 months | 18 (8) | 13 (3) | 23 (10) | 18 (8) | |
| Mean difference | +1 | +7 | +9 | 0.45 | 0.045† |
| vWF+ per myofibre (%) | |||||
| 0 months | 0.8 (0.04) | 0.5 (0.1) | 0.5 (0.1) | 0.6 (0.2) | |
| 3 months | 1.1 (0.2) | 1.0 (0.2) | 1.1 (0.4) | 1.1 (0.2) | |
| Mean difference | +0.3 | +0.5 | +0.6 | 0.33 | < 0.001† |
| CD56+ myofibres (%) | |||||
| 0 months | 16 (n/a)‡ | 18 (6) | 25 (3) | 21 (5)§ | |
| 3 months | 16 (n/a)‡ | 18 (8) | 21 (12) | 19 (7)§ | |
| Mean difference | 0 | 0 | -4 | 0.94 | 0.60† |
* comparison of mean differences between time points between the groups (one-way analysis of variance (ANOVA) † difference between time points for all patients (paired t-test) ‡ standard deviation not available as only one observation was made § for total seven patients