Table 1.

Quantification of tissue pathology during acute T. gondii infection following anti-CD25 antibody administration

Days post-inoculation	Treatment	Liver		Ileum lesions
		Liver damage	Inflammatory responses
8	Controls	3.0 (3.0–4.0)	3.0 (2.0–3.0)	1.0 (1.0–2.0)
	PC61	1.0 (1.0–2.0)	1.0 (1.0–1.0)	3.0 (2.0–3.0)

Liver and ileal lesions were semi-quantitatively scored based on our previous scoring systems (28, 31).

Liver damage: 1, degeneration and necrosis of individual hepatocytes occasionally seen; 2, clusters or small aggregates of hepatocyte degeneration and necrosis; 3, medium to large aggregates of hepatocyte necrosis; 4, large areas of hepatocyte necrosis with loss of normal liver anatomic architecture.

Intensity of the inflammatory response: 1, small inflammatory infiltrates with a few inflammatory cells; 2, medium-size inflammatory infiltrates with small to moderate numbers of inflammatory cells; 3, large inflammatory infiltrates with moderate to large numbers of inflammatory cells; 4, extensive infiltration with large numbers of inflammatory cells.

The ileal lesions were scored for the degeneration and necrosis of villous epithelial cells, transmural inflammation, and lamina propria and crypt inflammation and an integer score between 0 (unremarkable) and 4 (severe) was assigned.

The values are medium with ranges in the parenthesis from five individual mice.