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18F-FLT PET imaging of response to cetuximab. (A) Representative pretreatment and posttreatment coronal maximum-intensity projection PET images from mice treated with cetuximab or placebo are shown. (B) Relative change in standard uptake value (Δ-SUV) is plotted for each animal imaged and the median value for each treatment group is shown. (C) A similar analysis is shown for the relative change in tumor to muscle activity ratio (Δ-TMR).
