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. 2013 Jul 5;75(11):1449–1454. doi: 10.1292/jvms.13-0189

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©2013 The Japanese Society of Veterinary Science

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.

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Fig. 1. — Effects of arachidonic acid, γ-linolenic acid and linoleic acid on insulin secretion. In pancreatic perfusion experiments, an equilibration period of 20 min preceded time 0. After a baseline period of 10 min, arachidonic acid, or γ-linolenic acid or linoleic acid (100 µM) was administered for 30 min followed by basal medium (KRB) perfusion. The horizontal line indicates the presence of arachidonic acid, γ-linolenic acid and linoleic acid. Values are means ± SE (n=4). Baseline effluent concentrations of insulin were 4,172 ± 277 pg/ml, 2,384 ± 802 pg/ml, 3,541 ± 508 pg/ml and 1,199 ± 127 pg/ml for the control, arachidonic acid, γ-linolenic acid and linoleic acid groups, respectively.