Fig. 2.

Effect of linoleic acid on insulin release. In pancreatic perfusion experiments, an equilibration period of 20 min preceded time 0. After a baseline period of 10 min, linoleic acid (10, 50, 100 and 150 µM) was administered for 30 min followed by basal medium (KRB) perfusion. The horizontal line indicates the presence of linoleic acid. Values are means ± SE (n=4). Baseline effluent concentrations of insulin were 4,172 ± 277 pg/ml, 1,660 ± 352 pg/ml, 1,910 ± 172 pg/ml, 1,199 ± 127 pg/ml and 4,271 ± 1,739 pg/ml for the control group and 10, 50, 100 and 150 µM linoleic acid groups, respectively.