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. Author manuscript; available in PMC: 2014 Mar 5.
Published in final edited form as: Stroke. 2012 Mar 8;43(5):1383–1389. doi: 10.1161/STROKEAHA.111.641522

Figure 1. GDQ preconditioning reduces Ischemic injury.

Figure 1

(A) C57Bl/6 mice were preconditioned with escalating doses of GDQ (N = 8; 10, 20 or 40 μg per mouse; s.c.) or saline (N = 5) 72hr prior to 60 min MCAO. Infarct size was determined 24 hr following MCAO. (B) C57Bl/6 mice were pre-treated with GDQ (N = 8; 20 μg/mouse, s.c.) or saline (n = 6) 72hr prior to MCAO. Infarct size was determined 72 hr following MCAO. (C) C57Bl/6 mice were pre-treated with GDQ (N = 5 – 6; 20 μg/mouse, s.c.) or saline (n = 6) at various times prior to MCAO. Infarct size was determined 24 hr following MCAO. Two-way ANOVA, Bonferroni post hoc, *p<0.01, **p<0.01, ***p<0.001 versus saline controls. (D&E) C57BL/6 mice were treated with GDQ (N = 5; 40 μg/mouse, s.c.) or saline (N = 6) 72hr prior to MCAO (60 min). Mice were then examined using the (D) neurological score (focal and general) and (E) corner test to determine neurological and sensorimotor deficits 24hr following MCAO. Student’s t-test, *p<0.01, **p<0.01, ***p<0.001 versus saline controls.