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. Author manuscript; available in PMC: 2014 Mar 5.
Published in final edited form as: Stroke. 2012 Mar 8;43(5):1383–1389. doi: 10.1161/STROKEAHA.111.641522

Figure 3. TNFα is not required for TLR7-induced neuroprotection.

Figure 3

(A) C57Bl/6 mice were injected with either GDQ (40 ug/mouse, s.c.), LPS (20 μg/mouse, s.c.), or saline. Blood was collected at various time-points following injection and serum levels of TNFα determined via ELISA; N.D.= not detected (N = 4 – 6). (B) TNFα−/− (N = 6 – 8) and TNF+/+ mice (N = 7) were injected with GDQ (40 μg/mouse, s.c.) or saline 72hr prior to MCAO (50 min). Infarct size was determined 24hr following MCAO. Two-way ANOVA, Bonferroni post hoc, *p<0.05, ***p<0.001 versus saline controls.