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. Author manuscript; available in PMC: 2014 Mar 5.
Published in final edited form as: Stroke. 2012 Mar 8;43(5):1383–1389. doi: 10.1161/STROKEAHA.111.641522

Figure 5. IFNAR signaling is required for TLR7-mediated neuroprotection.

Figure 5

IFNAR+/+ and IFNAR−/− mice were injected with GDQ (N = 6 – 8), CpG (N = 8 – 11), LPS (N = 8 – 11) or saline (N = 6 – 9) 72hr prior to MCAO (45 min). Infarct size was determined 24hr following MCAO. The data are presented as percent damage normalized to saline + MCAO. Two-way ANOVA, Bonferroni post hoc, ***p<0.001 versus saline control for respective genotype; #p<0.05 versus IFNAR+/+ for respective treatment.