Scheme 1.
Synthesis of 5, conditions: a. dichloromethane, triethylamine, (70 - 88% yield); b. trifluoroacetic acid, dichloromethane, 0°C warm to RT (100% yield); c. EDC, HOBT, NMM, DMF, (40-55%)
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.