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Therapeutic endogenous expression of human IL-10 in murine thymus increases survival in septic IL-10 knockout mice. IL-10−/− mice receiving the human IL-10 vector prior to CLP (▼) demonstrated a significant survival benefit compared to IL-10−/− mice pretreated with an empty vector (○) or buffer solution only (●). *P < 0.05 as determined by log-rank test in Kaplan–Meier survival analyses.
