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Intrathymic expression of human IL-10 in septic IL-10 knockout mice reduces plasma concentrations of murine IL-6. IL-10−/− mice receiving intrathymic injections of Adv/hIL-10 prior to CLP showed significantly reduced plasma concentrations of mruine IL-6 when compared to knockout mice treated with the empty vector or buffer only. *P < 0.05 as determined by Student’s t-test (Adv/hIL-10 versus Adv/empty). †P < 0.05 as determined by Student’s t-test (Adv/hIL-10 versus buffer).
