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Gclm−/− mice are an adequate model of GSH depletion.
A: GSH content in the livers of wt and Gclm−/− mice before and after PH. *= p<0.05 by one-way ANOVA. GSH: glutathione; PH: partial hepatectomy; wt: wild type; Gclm: glutamate cysteine ligase modifier subunit.
B: GCL activity in the livers of Gclm−/− and wt mice before and after PH. *=p<0.05 by one-way ANOVA. GCL: glutamate cysteine ligase; n=3–6 mice per genotype per time point.
