Table 7.
Hazard ratios (95% CI) for categorical cumulative exposure, and coefficients (95% CI) for continuous cumulative exposure
| Low exposure | Medium exposure | High exposure | Cumulative exposure | Log 10 cumulative exposure | |
|---|---|---|---|---|---|
|
a. Kidney cancer (N=42) | |||||
| PCE |
1.40 (0.54, 3.58) N=8 |
1.82 (0.75, 4.42) N=11 |
1.59 (0.66, 3.86) N=11 |
.00009 (-0.00048, 0.00065), p=.76 |
.0813 (-0.0553, 0.2179), p=.24 |
| TVOC |
1.42 (0.58, 3.47) N=10 |
1.44 (0.58, 3.59) N=10 |
1.54 (0.63, 3.75) N=11 |
.00001 (-0.00003, 0.00005) p=.59 |
.0633 (-0.0481, 0.1747) p=.26 |
|
b. Hodgkin lymphoma (N=24) | |||||
| TCE |
1.52 (0.42, 5.59) N=4 |
1.63 (0.43, 6.12) N=4 |
1.97 (0.55, 7.03) N=5 |
.00005 (-0.00003, 0.00013) p=.20 |
.0940 (-0.0650, 0.2530) p=.25 |
| VC |
1.20 (0.29, 4.94) N=3 |
2.07 (0.59, 7.27) N=5 |
1.99 (0.56, 7.13) N=5 |
.00056 (-0.00060, 0.00172) p=.34 |
.1101 (-0.0817, 0.3019) p=.26 |
| Benzene |
1.24 (0.30, 5.11) N=3 |
1.88 (0.54, 6.61) N=5 |
1.94 (0.54, 6.95) N=5 |
.00203 (-0.00339, 0.00745) p=.46 |
.1074 (-0.1088, 0.3236) p=.33 |
| TVOC |
0.66 (0.13, 3.39) N=2 |
1.77 (0.50, 6.25) N=5 |
2.17 (0.63, 7.50) N=6 |
.00003 (-0.00003, 0.00009) p=.24 |
.0752 (-0.0818, 0.2322) p=.35 |
|
c. Leukemias (N=66) | |||||
| TCE |
2.00 (1.00, 4.00) N=16 |
1.54 (0.71, 3.36) N=11 |
1.81 (0.85, 3.85) N=13 |
.00002 (-0.00004, 0.00008) p=.46 |
.0801 (-0.0093, 0.1695) p=.08 |
| Benzene |
2.54 (1.27, 5.08) N=17 |
1.46 (0.66, 3.20) N=11 |
1.69 (0.77, 3.67) N=12 |
.00168 (-0.00158, 0.00494) p=.31 |
.1276 (0.0020, 0.2532) p=.05 |
| TVOC |
2.50 (1.24, 5.03) N=19 |
1.33 (0.56, 3.14) N=9 |
2.33 (1.08, 5.03) N=15 |
.00001 (-0.00003, 0.00005) p=.44 |
.0950 (0.0032, 0.1868) p=.04 |
|
d. ALS (N=21) | |||||
| TCE |
0.91 (0.25, 3.23) N=4 |
0.87 (0.21, 3.57) N=3 |
1.93 (0.65, 5.79) N=8 |
.00007 (0.00001, 0.00013) p=.04 |
.0436 (-0.1083, 0.1955) p=.57 |
| PCE |
0.69 (0.13, 3.55) N=2 |
1.58 (0.45, 5.50) N=5 |
1.96 (0.64, 6.02) N=8 |
.00039 (-0.00002, 0.00080) p=.06 |
.0836 (-0.1060, 0.2732) p=.39 |
| VC |
1.22 (0.33, 4.51) N=4 |
0.91 (0.22, 3.87) N=3 |
2.21 (0.71, 6.86) N=8 |
.00110 (0.00020, 0.00200) p=.02 |
.0724 (-0.1149, 0.2597) p=.45 |
| TVOC | 1.27 (0.37, 4.41) N=5 | 0.89 (0.21, 3.82) N=3 | 2.11 (0.67, 6.68) N=8 | .00005 (0.00001, 0.00009) p=.03 | .0702 (-0.0872, 0.2276) p=.38 |
TCE: Trichloroethylene PCE: Tetrachloroethylene (or perchloroethylene) VC: Vinyl chloride.
TVOC: (“total volatile organic compounds”) the sum of all contaminants (TCE, PCE, trans-1,2-dichloroethylene, vinyl chloride and benzene) in the drinking water.
The referent group for each contaminant consists of those Camp Lejeune cohort members with cumulative exposures within the reference level for that contaminant shown in Table 6.
Exposure lagged 10 years. Adjusted for race, sex, rank and education. Selected causes of death. Camp Lejeune cohort (N = 154,932).