Table 4.
Top 10 genes showing association via gene-based association analysis in European- and African-American subsamples analyzed separately.
| Gene | Chromosome | Start basepair | End basepair | P-value (EA) | P-value (AA) |
|---|---|---|---|---|---|
| European-American subsample (N=2,018) | |||||
| C17orf58 | 17 | 63417678 | 63420227 | <1E-6 | 0.422 |
| PPM1D | 17 | 56032335 | 56096818 | <1E-6 | 0.149 |
| BPTF | 17 | 63252241 | 63410956 | 0.000001 | 0.351 |
| UNC119B | 12 | 11963221 | 11964582 | 0.000016 | 0.11 |
| LRRC37A3 | 17 | 60280949 | 60345365 | 0.000026 | 0.618 |
| ACADS | 12 | 11964795 | 11966219 | 0.000027 | 0.119 |
| KIAA0152 | 12 | 11960933 | 11962405 | 0.000033 | 0.136 |
| MYEF2 | 15 | 46218920 | 46257850 | 0.000137 | 0.944 |
| CABP1 | 12 | 11956280 | 11958951 | 0.000161 | 0.288 |
| ZNF681 | 19 | 23713836 | 23733533 | 0.000164 | 0.24 |
| African-American subsample (N=1,035) | |||||
| PTCHD3 | 10 | 27727122 | 27743303 | 0.000125 | 0.61 |
| AFF3 | 2 | 99530147 | 10012546 | 0.000381 | 0.466 |
| FILIP1L | 3 | 10103467 | 10131603 | 0.000415 | 0.224 |
| C3orf26 | 3 | 10101937 | 10138013 | 0.000527 | 0.215 |
| CNOT10 | 3 | 32701701 | 32790358 | 0.000556 | 0.171 |
| FANCM | 14 | 44674885 | 44739843 | 0.000565 | 0.407 |
| IAPP | 12 | 21417084 | 21423683 | 0.000588 | 0.493 |
| NMUR2 | 5 | 15175129 | 15176503 | 0.000603 | 0.674 |
| FKBP3 | 14 | 44654858 | 44674272 | 0.000668 | 0.311 |
| CCDC91 | 12 | 28301399 | 28594366 | 0.000686 | 0.257 |