Fig. 2.
A–B. Plasma Nitrite prior to and following a maximal Cardiopulmonary Exercise Testing (CPX). Changes in (A) Circulating plasma nitrite concentration (nM) and (B) plasma nitrite flux (% change in plasma nitrite concentration for pre to post CPX) at baseline (Base) and following 3 month supervised exercise training (3 M). (A) Samples were collected prior to (Rest), and 10 min following maximal CPX (CPX). * = significantly different within groups at the p ≤ 0.05 level. δ = significantly lower than control subjects CPX values by ANOVA at the p ≤ 0.05 level. ∞ = p ≤ 0.05 for group*time interaction using a repeated measures analyses of variance. PAD = peripheral arterial disease subjects, T2D + PAD = peripheral arterial disease subjects with type 2 diabetes mellitus, CON = Controls.