Table 1.
Summary of PTX nanocrystal size and PDI under various processing conditions
| Average particle size (nm) | PDI | ||
|---|---|---|---|
| Solvent | Ethanol | 287± 8 | 0.20 |
| Methanol | 280±15 | 0.15 | |
| DCM | 338±13 | 0.09 | |
| EA | 418±20 | 0.20 | |
| DMSO | 353±13 | 0.21 | |
| PTX concentration | 1 mg/ml | 296±12 | 0.13 |
| 3 mg/ml | 268±8 | 0.20 | |
| 5 mg/ml | 1,670±89 | 0.40 | |
| 9 mg/ml | 4,421±144 | 0.39 | |
| 12 mg/ml | 4,358±103 | 0.32 | |
| Antisolvent-solvent ratio | 40:1 | 291±10 | 0.12 |
| 20:1 | 287±8 | 0.20 | |
| 10:1 | 518±19 | 0.30 | |
| 5:1 | 746±25 | 0.30 | |
| Stabilizer | HPMC | 490±19 | 0.25 |
| PVP | 514±23 | 0.19 | |
| PEG400 | 303±11 | 0.14 | |
| Pluronic F68 | 330±18 | 0.20 | |
| Pluronic F127 | 278±10 | 0.20 | |
| Tween 20 | 353±14 | 0.14 | |
| Tween 80 | 290±12 | 0.19 | |
| SDS | 379±21 | 0.17 |