Table 2.

Association for independent, established MS susceptibility loci with ALS

Chromosome	Rsid	Position (hg19)	Gene	Risk allele	P MS	OR MS	P ALS	OR ALS
1	rs4648356	2709164	MMEL1 (TNFRSF14)	C	0.012	1.09	0.97	1.00
1	rs11810217	93148377	EVI5	T	0.00032	1.14	0.12	0.94
1	rs11581062	101407519	SLC30A7	G	0.032	1.08	0.025	1.08
1	rs1335532	117100957	CD58	A	1.2E-08	1.35	0.97	1.00
1	rs1323292	192541021	RGS1	A	0.0098	1.11	0.53	1.03
1	rs7522462	200881595	C1orf106	G	0.00083	1.13	0.023	0.92
2	Rs6718520a (4)	43325570	ZFP36L2 (THADA)	A	1.2E-05	1.16	0.84	1.01
2	rs12466022	43359061	ZFP36L2 (THADA)	C	4.2E-05	1.16	0.76	0.99
2	rs7595037	68647095	PLEK	T	1.6E-05	1.15	0.32	0.97
2	rs17174870	112665201	MERTK	C	0.00012	1.15	0.79	1.01
2	rs10201872	231106724	SP140	T	0.00056	1.15	0.13	1.07
3	rs669607	28071444	intergenic	C	2.5E-05	1.15	0.57	0.98
3	rs2028597	105558837	CBLB	G	0.56	1.03	0.52	1.04
3	rs2293370	119219934	C3orf1	G	0.056	1.08	0.29	0.96
3	rs9282641	121796768	CD86	G	0.0015	1.22	0.52	0.96
3	rs2243123	159709651	IL12A	C	0.17	1.05	0.25	1.04
4	rs228614	103578637	MANBA	G	0.0092	1.18	0.23	0.625
5	rs6897932	35874575	IL7R	C	0.0014	1.12	0.20	0.96
5	rs4613763	40392728	PTGER4	C	0.00014	1.19	0.87	0.99
5	rs2546890	158759900	IL12B	A	3.8E-06	1.16	0.78	1.01
6	rs12212193	90996769	BACH2	G	0.0055	1.09	0.14	1.05
6	rs802734	128278798	PTPRK	A	0.0014	1.12	0.89	1.00
6	rs11154801	135739355	AHI1	A	0.014	1.08	0.49	0.98
6	rs17066096	137452908	IL22RA2	G	0.00096	1.13	0.29	0.96
6	rs1738074	159465977	TAGAP	C	0.00075	1.12	0.45	0.98
7	rs354033	149289464	ZNF767	G	0.00079	1.13	0.26	1.04
8	rs1520333	79401038	PKIA	G	0.11	1.06	0.41	1.03
8	rs4410871	128815029	MYC	C	0.018	1.09	0.54	1.02
9	rs2150702	5893861	MLANA	G	2.5E-05	1.14	0.015	1.08
10	rs3118470	6101713	IL2RA	C	0.00078	1.12	0.76	1.01
10	rs1250550	81060317	ZMIZ1	A	0.0024	1.11	0.66	0.98
10	rs7923837	94481917	HHEX	G	0.015	1.08	0.18	0.96
11	rs650258	60832282	CD5	C	0.00018	1.14	0.097	0.95
11	rs630923	118754353	CXCR5	C	0.033	1.11	0.066	1.08
12	rs1800693	6440009	TNFRSF1A	G	NAb	NA	0.67	1.01
12	rs10466829	9876091	CLECL1	A	0.0009	1.11	0.49	0.98
12	rs12368653	58133256	AGAP2	A	0.0018	1.10	0.31	0.97
12	rs949143	123595163	ARL6IP4	G	0.015	1.08	0.57	0.98
14	rs4902647	69254191	ZFP36L1	C	0.00022	1.12	0.72	0.99
14	rs2300603	76005557	BATF	T	0.014	1.10	0.10	0.94
14	rs2119704	88487689	GPR65	C	0.045	1.13	0.23	0.93
16	rs2744148	1073552	SOX8	G	0.023	1.10	0.30	0.95
16	rs7200786	11177801	CLEC16A	A	8.8E-05	1.14	0.58	0.98
16	rs13333054	86011033	IRF8	T	0.063	1.09	0.98	1.00
17	rs9891119	40507980	STAT3	C	0.00016	1.13	0.86	0.99
17	rs180515	58024275	RPS6KB1	G	0.093	1.06	0.74	1.01
18	rs7238078	56384192	MALT1	T	0.00075	1.13	0.99	1.00
19	rs1077667	6668972	TNFSF14	C	0.033	1.10	0.10	0.94
19	rs8112449	10520064	CDC37	G	0.14	1.05	0.83	0.99
19	rs874628	18304700	MPV17L2	A	0.021	1.09	0.65	0.98
19	rs2303759	49869051	DKKL1	G	0.0075	1.11	0.034	1.08
20	rs2425752	44702120	NCOA5	T	0.0001	1.14	0.40	0.97
20	rs2248359	52791518	CYP24A1	C	0.00085	1.12	0.29	1.04
20	rs6062314	62409713	ZBTB46	T	0.047	1.14	0.52	1.04
22	rs2283792	22131125	MAPK1	G	0.00036	1.12	0.23	1.04
22	rs140522	50971266	ODF3B	T	0.0022	1.12	0.72	0.99

Source of variants: (3), except where specified: (4).

^ar² = 0.15 with adjacent variant rs12466022, ^bNo SNP with r² > 0.6.