Figure 5.
Total resting time (A), distance moved (B) and rearing events (C) improvement in exercise fatigue assay of sildenafil-treated mdx5cv mice. Activity was recorded in 10-week-old mice, following 6 weeks of drug treatment. Clear differentiation was seen in this assay after the 6-week treatment period (*P = 0.0016, **P = 0.0011, ***P = 0.03, repeated-measures ANOVA), with no large differences detected after 2 and 4 weeks of treatment. Mdx5cv mice were given water at a 400 mg/l concentration of sildenafil (green). Mdx5cv (light blue) and strain-matched C57Bl6/J wild type (dark blue) received vehicle (n = 4 mice with two females and two males.).