Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Cell proliferation and angiogenesis requires interaction between the cell and the extracellular matrix that is mediated by integrins. Endogenous RGD peptides bind to integrins and anchor migrating and dividing cells. The desired mode of action of RGD antagonists is to block endogenous RGD peptide binding, thus preventing continued cellular proliferation and angiogenesis.
