Figure 4.

A hypothetical model explaining the effects of the PAT-Plat protocol. (a) General model for PAT-Plat effects. Irradiation leads to cellular damages such as DNA SSB and DSB directly or indirectly via the creation of reactive oxygen species. These damages are less likely repaired thanks to the inhibition of certain repair pathways by the cisplatin. Moreover, the PAT-Plat reduces the perfused vascular surface. This reduction of the perfusion can indirectly induce tumor cell death. (b) Schematic representation of the regression observed on a F98 glioma one month after the treatment. Grey area: part of the tumor that has disappeared after the whole treatment. The black arrow indicates the tumor volume reduction. (c) Macrophotograph of a F98 glioma one month after the whole treatment. Note that the dark spots show the blood vessel coagulations after the whole PAT-Plat treatment (white arrows).