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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2014 Jan 8;275(2):73–78. doi: 10.1016/j.taap.2013.12.023

Figure 1. METH-induced percent change in interstitial pO2 levels and LiPc implant in the striatum of mice.

Figure 1

Figure 1

Figure 1

For all experiments, LiPc crystal was implanted in the mouse brain 48 hr before EPR measurement and EPR spectra were collected each day before and after injection of METH (8 mg/kg i.v. per day) or vehicle (0.9% saline i.v.) from mice breathing 21% oxygen and converted to pO2. The 0 time point is time of injection. (A) Percent change in interstitial pO2 levels in the striatum of mice injected with METH for 3 days (*P < 0.05 vs Day 1 and Day 2 at the same time point). (B) Percent change in interstitial pO2 levels in the striatum of vehicle mice were injected with vehicle for 3 days as a control. Data are expressed as the Mean ± SEM (N=6 for each group). (C) A representative in vivo MR image of a mouse implanted with LiPc crystal (arrow) confirmed using T2-weighted 2D RARE imaging.