Table II.

Results of Gene by Environment Analysis.

CHR	SNP	Beta Estimate for SNP	SE	Beta Estimate for ICS Exposure	SE2	MAF	HWE p value	A1	A2	CAMP P_GXE	LOCCS P_GXE	Combined P_GXE
19	rs10411428	0.042	0.0099	−0.027	0.0087	0.41	0.17	T	C	1.41x10−7	0.00036	1.24x10−9
19	rs11666341	0.042	0.0098	−0.027	0.0087	0.45	0.17	A	G	1.62x10−7	0.00036	1.42x10−9
19	rs12460587*	0.035	0.0097	−0.029	0.0085	0.33	0.22	G	T	5.69x10−7	0.00018	2.43x10−9
19	rs3450	0.031	0.0099	−0.030	0.0082	0.18	0.72	C	T	1.93x10−6	0.00017	7.56x10−9
19	rs3752120**	0.032	0.0107	−0.031	0.0090	0.15	0.21	T	C	4.58x10−6	0.00050	4.81x10−8
19	rs2288884	0.033	0.0107	−0.031	0.0090	0.34	0.40	T	C	4.91x10−6	0.00050	5.14x10−8
8	rs6469488	0.072	0.0170	−0.032	0.0127	0.07	0.79	G	A	5.54x10−7	0.77	6.70x10−6
21	rs4919929	0.062	0.0153	−0.031	0.0122	0.07	0.42	T	C	1.96x10−6	0.79	2.22x10−5
3	rs9868563	0.099	0.0190	−0.012	0.0138	0.06	0.10	T	C	2.62x10−6	0.60	2.25x10−5
3	rs4686399	0.041	0.0094	−0.015	0.0068	0.29	0.41	G	A	1.87x10−6	0.87	2.33x10−5
3	rs1889261	0.084	0.0180	−0.018	0.0134	0.06	0.76	A	G	4.14x10−6	0.45	2.66x10−5
2	rs4233808	0.041	0.0100	−0.019	0.0089	0.16	0.69	G	A	8.84x10−6	0.72	8.20x10−5

This table summarizes the results of testing and replication in CAMP and LOCCS using the additive model sorted by combined population-based P values. The beta estimate for each SNP and for ICS exposure are provided. CHR=chromosome. SNP=single nucleotide polymorphism. SE= standard error. ICS=inhaled corticosteroid.

^*located in ZNF841.

^**located in ZNF432.