Table 6.
Multivariate Analysis for Incidence of Fibrotic Scar and Nonfibrotic Scar within 2 Years
| Fibrotic Scar vs. No Scar |
Nonfibrotic Scar vs. No Scar |
|||||||
|---|---|---|---|---|---|---|---|---|
| Baseline Characteristics |
Subjects
(N=799) |
Fibrotic
Scar, n (%) |
Adjusted Hazard
Ratio (95% CI) * |
P Value * |
Subjects
(N=765) |
Nonfibrotic
Scar, n (%) |
Adjusted Hazard
Ratio (95% CI) * |
P Value * |
| Baseline visual acuity in study eye | ||||||||
| 20/25–40 | 290 | 45 (15.5) | 1.00 | 0.004 | 333 | 87 (26.1) | 1.00 | 0.33 |
| 20/50–80 | 307 | 103 (33.6) | 1.61 (1.10–2.35) | 280 | 76 (27.1) | 0.91 (0.66–1.25) | ||
| 20/100–160 | 152 | 76 (50.0) | 2.14 (1.42–3.22) | 121 | 43 (35.5) | 1.12 (0.77–1.62) | ||
| 20/200–320 | 50 | 26 (52.0) | 1.52 (0.86–2.68) | 31 | 7 (22.6) | 0.55 (0.25–1.22) | ||
| Baseline area of CNV (disc areas) | ||||||||
| ≤1 | 296 | 88 (29.7) | 1.00 | 0.019 | 331 | 121 (36.6) | 1.00 | 0.04 |
| >1–≤2 | 173 | 57 (33.0) | 1.70 (1.16–2.50) | 152 | 36 (23.7) | 0.77 (0.52–1.15) | ||
| >2–≤4 | 174 | 50 (28.7) | 1.42 (0.95–2.14) | 152 | 28 (18.4) | 0.60 (0.39–0.93) | ||
| >4 | 88 | 23 (26.1) | 1.24 (0.73–2.12) | 77 | 11 (14.3) | 0.48 (0.25–0.91) | ||
| Missing | 68 | 32 (47.1) | 2.03 (1.25–3.31) | 53 | 17 (32.1) | 1.12 (0.66–1.88) | ||
| Lesion type | ||||||||
| Occult only | 516 | 85 (16.5) | 1.00 | <0.0001 | 532 | 98 (18.4) | 1.00 | <0.0001 |
| Minimally classic | 109 | 55 (50.5) | 2.76 (1.92–3.97) | 89 | 35 (39.3) | 2.39 (1.61–3.56) | ||
| Predominantly classic | 174 | 110 (63.2) | 4.14 (2.84–6.03) | 144 | 80 (55.6) | 3.11 (2.23–4.32) | ||
| Blocked fluorescence | ||||||||
| No | 694 | 186 (26.8) | 1.00 | 0.0004 | 690 | 179 (25.9) | 1.00 | 0.41 |
| Yes | 105 | 64 (61.0) | 1.84 (1.32–2.58) | 75 | 34 (45.3) | 1.18 (0.79–1.75) | ||
| Retinal thickness at foveal center (μm) |
||||||||
| <120 | 87 | 18 (20.7) | 1.00 | <0.0001 | 86 | 17 (19.8) | 1.00 | 0.08 |
| 120–212 | 421 | 112 (26.3) | 1.67 (0.99–2.80) | 433 | 117 (27.0) | 1.58 (0.95–2.65) | ||
| >212 | 286 | 120 (42.0) | 2.73 (1.60–4.66) | 245 | 79 (32.2) | 1.83 (1.07–3.11) | ||
| Subretinal tissue complex thickness at foveal center (μm) |
||||||||
| >0–≤75 | 202 | 33 (16.3) | 1.00 | <0.0001 | 214 | 45 (21.0) | 1.00 | 0.11 |
| >75–≤160 | 180 | 58 (32.2) | 1.57 (1.00–2.48) | 189 | 65 (34.4) | 1.58 (1.07–2.34) | ||
| >160–≤275 | 194 | 71 (36.6) | 2.08 (1.32–3.26) | 186 | 63 (33.9) | 1.44 (0.96–2.14) | ||
| >275 | 223 | 88 (39.5) | 3.11 (1.96–4.94) | 175 | 40 (22.9) | 1.18 (0.76–1.83) | ||
| Subretinal fluid | ||||||||
| No fluid | 139 | 34 (24.5) | 1.00 | 0.012 | 141 | 36 (25.5) | 1.00 | 0.74 |
| Fluid not at foveal center | 371 | 125 (33.7) | 1.03 (0.68–1.54) | 352 | 106 (30.1) | 1.16 (0.79–1.71) | ||
| Fluid at foveal center | 289 | 91 (31.5) | 1.60 (1.04–2.46) | 271 | 71 (26.2) | 1.12 (0.75–1.68) | ||
| RPE elevation | ||||||||
| No | 97 | 54 (55.7) | 1.00 | <0.0001 | 79 | 36 (45.6) | 1.00 | 0.07 |
| Yes | 702 | 196 (27.9) | 0.50 (0.36–0.70) | 682 | 175 (25.7) | 0.71 (0.49–1.03) | ||
| SHRM | ||||||||
| No | 204 | 27 (13.2) | 1.00 | 0.008 | 208 | 31 (14.9) | 1.00 | 0.004 |
| Yes | 595 | 223 (37.5) | 1.82 (1.17–2.83) | 557 | 182 (32.7) | 1.78 (1.20–2.64) | ||
| Drug | ||||||||
| Ranibizumab | 428 | 130 (30.4) | 1.00 | 0.85 | 396 | 98 (24.8) | 1.00 | 0.16 |
| Bevacizumab | 371 | 120 (32.4) | 1.03 (0.78–1.34) | 369 | 115 (31.2) | 1.22 (0.93–1.60) | ||
| Regimen† | ||||||||
| Monthly for 2 yrs | 205 | 64 (31.2) | 1.00 | 0.13 | 189 | 48 (25.4) | 1.00 | 0.81 |
| Monthly for 1 yr, PRN for 2 yrs | 197 | 67 (34.0) | – | 186 | 55 (29.6) | – | ||
| PRN for 2 yrs | 397 | 119 (30.0) | 0.81 (0.62–1.07) | 390 | 110 (28.2) | 1.04 (0.78–1.39) | ||
CI = confidence interval; CNV = choroidal neovascularization; PRN = pro re nata; RPE = retinal pigment epithelium; SHRM = subretinal hyperreflective material.
Note: All results not in italics are from the final multivariate model. The results in italics are from the multivariate model with adjustment of all variables in the final model.
*
From a time-dependent Cox proportional hazards model.
†
Regimen was a time-dependent variable with a value of monthly or PRN.