Table 7.
Association of Genotype with the Incidence of Scar within 2 Years (N = 797)
|
Subjects at Risk,
n |
Scar at Week 52
or 104, n (%) * |
Univariate Analysis
|
Adjusted Analysis
|
||
|---|---|---|---|---|---|
| SNP § | Genotype | Hazard Ratio (95% CI) † | Hazard Ratio (95% CI) ‡ | ||
| CFH rs1061170 | CC | 258 | 125 (48.5) | 1.01 (0.76–1.34) | 1.02 (0.77–1.36) |
| TC | 370 | 164 (44.3) | 0.90 (0.69–1.18) | 0.91 (0.70–1.19) | |
| TT | 169 | 82 (48.5) | 1.00 | 1.00 | |
| Linear trend P | 0.88 | 0.83 | 0.77 | ||
| Adjusted P∥ | 0.78 | ||||
| ARMS2 rs10490924 | TT | 163 | 76 (46.6) | 1.06 (0.80–1.42) | 1.06 (0.79–1.38) |
| GT | 371 | 177 (47.7) | 1.11 (0.88–1.40) | 1.09 (0.86–1.38) | |
| GG | 263 | 118 (44.9) | 1.00 | 1.00 | |
| Linear trend P | 0.65 | 0.60 | 0.64 | ||
| Adjusted P∥ | 0.78 | ||||
| HTRA1 rs11200638 | AA | 155 | 74 (47.7) | 1.10 (0.83–1.48) | 1.10 (0.82–1.47) |
| AG | 371 | 176 (47.4) | 1.10 (0.87–1.39) | 1.10 (0.87–1.39) | |
| GG | 271 | 121 (44.7) | 1.00 | 1.00 | |
| Linear trend P | 0.49 | 0.45 | 0.48 | ||
| Adjusted P∥ | 0.78 | ||||
| C3 rs2230199 | GG | 55 | 27 (49.1) | 1.06 (0.71–1.59) | 1.08 (0.72–1.62) |
| CG | 303 | 131 (43.2) | 0.84 (0.67–1.04) | 0.85 (0.68–1.07) | |
| CC | 439 | 213 (48.5) | 1.00 | 1.00 | |
| Linear trend P | 0.41 | 0.40 | 0.52 | ||
| Adjusted P∥ | 0.78 | ||||
| CC | 397 | 172 (43.3) | 0.81 (0.57–1.16) | 1.00 (0.70–1.44) | |
| TLR3 rs3775291 | TC | 326 | 162 (49.7) | 0.99 (0.69–1.41) | 0.82 (0.57–1.18) |
| TT | 74 | 37 (50.0) | 1.00 | 1.00 | |
| Linear trend P | 0.10 | 0.08 | 0.08 | ||
| Adjusted P∥ | 0.48 | ||||
| No. of risk alleles | 0–2 | 85 | 47 (55.3) | 1.00 | 1.00 |
| 3 | 112 | 46 (41.1) | 0.67 (0.45–1.01) | 0.67 (0.44–1.01) | |
| 4 | 154 | 70 (45.5) | 0.76 (0.53–1.11) | 0.76 (0.52–1.10) | |
| 5 | 173 | 81 (46.8) | 0.81 (0.56–1.16) | 0.82 (0.57–1.17) | |
| 6 | 136 | 65 (47.8) | 0.86 (0.59–1.25) | 0.85 (0.58–1.25) | |
| ≥7 | 137 | 62 (45.3) | 0.76 (0.52–1.11) | 0.76 (0.52–1.12) | |
| Linear trend P | 0.71 | 0.75 | 0.78 | ||
| Adjusted P∥ | 0.78 |
ARMS2 = age-related maculopathy susceptibility 2; C3 = complement 3; CI = confidence interval; CFH = complement factor H; HTRA1 = HtrA serine peptidase 1; TLR3 = toll-like receptor 3 gene.
Linear trend P value is from a logistic regression model with genotype coded as 0, 1, and 2 risk alleles.
Linear trend P value is from proportional hazards model with genotype coded as 0, 1, and 2 risk alleles.
Linear trend P value is from proportional hazard models adjusted for age, gender, and smoking status.
The risk alleles are C for CFH, T for ARMS2, A for HTRA1, G for C3, and C for TLR3.
The multiple testing adjusted P values were calculated using the approach of false discovery rate.