Figure 4.

Effect of d-amphetamine on dopamine efflux in the PFC of NK1R+/+ and NK1R−/− mice. Mice were given vehicle (Veh: Tween 80 in 0.9% saline) or RP 67580 (‘RP’, 5 mg/kg. i.p.) followed by a second injection of (A) saline (Sal) or (B) d-amphetamine (d-AMP: 2.5 mg/kg i.p.), as indicated by the arrows (see legend to Figure 3 for further details). Points show mean ± s.e. mean dopamine efflux in the LDEB (N = 3 or 4 per cell). Across the eight groups, there was a main effect of genotype in the basal samples (*: F_1,18 = 181.2; P < 0.001). When comparing efflux in the final bin of three samples with that in the basal samples, there was a bin × genotype × RP/vehicle interaction ($: F_1,18 = 6.7; P = 0.02). There was also an interaction (#) between genotype × RP/ vehicle in the final bin (F_1,18 = 5.9; P = 0.03)