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. 2014 Feb 12;10:384–393. doi: 10.3762/bjoc.10.36

Scheme 1.

Scheme 1

Conventional (from the left) and decarboxylative (from the right) Pd-catalyzed Sonogashira coupling reactions for the preparation of 4-(3-aminophenyl)-2-methyl-3-butin-2-ol (2a), which is used as an intermediate for the synthesis of Erlotinib hydrochloride (3).