Figure 3. Significant hand tendon defects are observed in Mkx-null mice.
The extensor tendons and flexor digitorum profundus (FDP), in P2, P21, and 7-month-old Mkx-null mice were dramatically reduced compared to those of the wild-type littermates. (A–G) Tendon appearance of wild-type (WT) (A–D) and mutant (E–G) digits at P2. (H–P) Tendon appearance of wild-type (WT) (H–L) and mutant (M–P) digits at P21. (Q–V) Tendon appearance of wild-type (WT) (Q, R) and mutant (S–V) digits at 7 months. Red arrowheads, FDP tendons. Yellow arrows, extensor tendons. The numbering of the tendons refers to that introduced by Watson et al. 25 as follows: 3, flexor digitorium sublimis (FDS); 4, flexor digitorium profundus (FDP); 5, extensor digitorium communis (EDC); 7, extensor pollicis; 8, extensor carpi ulnaris; 9, extensor carpi radialis longus; 10, extensor carpi radialis brevis; 11, extensor digiti quarti; 12, extensor digiti quinti; 13, flexor carpi radialis; 14, flexor carpi ulnaris; 15, palmaris longus.