Skip to main content
. Author manuscript; available in PMC: 2015 Apr 15.
Published in final edited form as: J Pharm Biomed Anal. 2014 Jan 9;92:63–68. doi: 10.1016/j.jpba.2014.01.001

Table 4.

Freeze/Thaw Stability in Plasma (A) or Plasma Pre-Stabilized with 0.1% HCl (B)

A 3 ng/mL 400 ng/mL
Freeze/Thaw Cycles GM (ng/mL) DEV from fresh (%) GM (ng/mL) DEV from fresh (%)
0 (Fresh) 2.57 - 382.1 -
1 2.30 −11.42 403.7 5.64
2 2.44 −6.26 342.9 −10.25
3 3.34 28.34 347.5 −9.06
4 2.27 −12.84 368.0 −3.68
B 3 ng/mL 400 ng/mL
Freeze/Thaw Cycles GM (ng/mL) DEV from fresh (%) GM (ng/mL) DEV from fresh (%)
0 (Fresh) 2.53 - 337.64 -
1 2.77 9.35 331.42 −1.84
2 2.69 6.28 340.82 0.94
3 2.62 3.49 337.59 −0.01
4 2.77 9.31 356.98 5.73

Abbreviations: GM, grand mean; DEV (%) relative deviation from nominal value