Figure 3. Model for dissolved drug release from cylindrical reservoirs.

(A) Accuracy of the two stage drug release model (Eqn. 11) for LNG segments stored 76 days at 40°C to completely equilibrate LNG loading throughout the cross-section. Experimental data represent N = 3, mean ± SD. Effects of (B) EG-65D RCM thickness (in µm) and (C) diffusivity (in cm²/s) on the reservoir-stage model (Eqn. 11b) for 20 mm length segments with 5.5 mm diameter. Effects of (D) PEU-2 RCM thickness, and (E) diffusivity on the burst duration (t_b) predicted by Equation 6. For panels C and E RCM thickness was fixed at 100 µm. (F) Maximal burst amount (M_b) shown as a function of RCM thickness.