Figure 2. Effects of MEAP and indometacin on ear edema induced by dimethylbenzene in mice.

The vehicle (control, 10 ml/kg) or the MEAP (400, 200, 100 and 50 mg/kg) was administered orally, and the indometacin (10 mg/kg) was given abdominally 1 h separately before each dimethylbenzene topical application to the right ear. Each column represents the mean ± SEM (n = 10). *P<0.05, **P<0.01, ***P<0.001, compared with control.