Table 5. Fas and FasL mRNA expression by the genotypes of SNPs, using data from the HapMap1.
| Fas -670A>G | FasL -844C>T | ||||||||
| Population | Genotypes | No. | Mean ± SD | P 2 | Ethnicity | Genotypes | No. | Mean ± SD | P 2 |
| CEU3 | AA | 23 | 8.79±0.36 | CEU3 | CC | 76 | 5.94±0.07 | ||
| GA | 46 | 8.87±0.28 | 0.321 | CT | 5 | 5.89±0.07 | 0.137 | ||
| GG | 12 | 8.74±0.36 | 0.687 | TT | 0 | — | — | ||
| Dominant | 58 | 8.84±0.30 | 0.511 | Dominant | 5 | 5.89±0.07 | 0.137 | ||
| Recessive | 69 | 8.84±0.31 | 0.292 | Recessive | 81 | — | — | ||
| YRI3 | AA | 6 | 8.58±0.33 | YRI3 | CC | 0 | — | — | |
| GA | 25 | 8.70±0.31 | 0.402 | CT | 28 | 5.94±0.06 | — | ||
| GG | 53 | 8.67±0.30 | 0.450 | TT | 53 | 5.95±0.06 | — | ||
| Dominant | 78 | 8.58±0.33 | 0.410 | Dominant | 81 | 5.95±0.06 | — | ||
| Recessive | 31 | 8.67±0.31 | 0.987 | Recessive | 28 | 5.94±0.06 | 0.493 | ||
| Asian3 | AA | 28 | 8.65±0.29 | Asian3 | CC | 0 | — | — | |
| GA | 36 | 8.78±0.26 | 0.059 | CT | 50 | 5.96±0.06 | — | ||
| GG | 21 | 8.98±0.30 | 0.0003 | TT | 33 | 5.91±0.06 | — | ||
| Dominant | 57 | 8.85±0.29 | 0.003 | Dominant | 83 | 5.94±0.06 | — | ||
| Recessive | 64 | 8.72±0.28 | 0.001 | Recessive | 50 | 5.96±0.06 | 0.001 | ||
| All3 | AA | 57 | 8.70±0.33 | All3 | CC | 76 | 5.94±0.07 | ||
| GA | 107 | 8.80±0.28 | 0.043 | CT | 83 | 5.95±0.06 | 0.163 | ||
| GG | 86 | 8.76±0.33 | 0.297 | TT | 86 | 5.94±0.06 | 0.913 | ||
| Dominant | 193 | 8.78±0.30 | 0.081 | Dominant | 169 | 5.95±0.06 | 0.390 | ||
| Recessive | 164 | 8.76±0.30 | 0.871 | Recessive | 159 | 5.95±0.06 | <0.0001 | ||
CEU: 90 Utah residents with ancestry from northern and western Europe; YRI: 90 Yoruba in Ibadan, Nigeria; Asian: 45 unrelated Han Chinese in Beijing and 45 unrelated Japanese in Tokyo.
1
Genotyping data and mRNA expression levels for Fas and FasL by genotypes were obtained from the HapMap phase II release 23 data from EBV-transformed lymphoblastoid cell lines from 270 individuals.
2
Two-side Student's t test within the stratum was used.
3
There were missing data for unavailable genotyping data.
Statistically significant results were in bold.