Table 5. Fas and FasL mRNA expression by the genotypes of SNPs, using data from the HapMap1.
Fas -670A>G | FasL -844C>T | ||||||||
Population | Genotypes | No. | Mean ± SD | P 2 | Ethnicity | Genotypes | No. | Mean ± SD | P 2 |
CEU3 | AA | 23 | 8.79±0.36 | CEU3 | CC | 76 | 5.94±0.07 | ||
GA | 46 | 8.87±0.28 | 0.321 | CT | 5 | 5.89±0.07 | 0.137 | ||
GG | 12 | 8.74±0.36 | 0.687 | TT | 0 | — | — | ||
Dominant | 58 | 8.84±0.30 | 0.511 | Dominant | 5 | 5.89±0.07 | 0.137 | ||
Recessive | 69 | 8.84±0.31 | 0.292 | Recessive | 81 | — | — | ||
YRI3 | AA | 6 | 8.58±0.33 | YRI3 | CC | 0 | — | — | |
GA | 25 | 8.70±0.31 | 0.402 | CT | 28 | 5.94±0.06 | — | ||
GG | 53 | 8.67±0.30 | 0.450 | TT | 53 | 5.95±0.06 | — | ||
Dominant | 78 | 8.58±0.33 | 0.410 | Dominant | 81 | 5.95±0.06 | — | ||
Recessive | 31 | 8.67±0.31 | 0.987 | Recessive | 28 | 5.94±0.06 | 0.493 | ||
Asian3 | AA | 28 | 8.65±0.29 | Asian3 | CC | 0 | — | — | |
GA | 36 | 8.78±0.26 | 0.059 | CT | 50 | 5.96±0.06 | — | ||
GG | 21 | 8.98±0.30 | 0.0003 | TT | 33 | 5.91±0.06 | — | ||
Dominant | 57 | 8.85±0.29 | 0.003 | Dominant | 83 | 5.94±0.06 | — | ||
Recessive | 64 | 8.72±0.28 | 0.001 | Recessive | 50 | 5.96±0.06 | 0.001 | ||
All3 | AA | 57 | 8.70±0.33 | All3 | CC | 76 | 5.94±0.07 | ||
GA | 107 | 8.80±0.28 | 0.043 | CT | 83 | 5.95±0.06 | 0.163 | ||
GG | 86 | 8.76±0.33 | 0.297 | TT | 86 | 5.94±0.06 | 0.913 | ||
Dominant | 193 | 8.78±0.30 | 0.081 | Dominant | 169 | 5.95±0.06 | 0.390 | ||
Recessive | 164 | 8.76±0.30 | 0.871 | Recessive | 159 | 5.95±0.06 | <0.0001 |
CEU: 90 Utah residents with ancestry from northern and western Europe; YRI: 90 Yoruba in Ibadan, Nigeria; Asian: 45 unrelated Han Chinese in Beijing and 45 unrelated Japanese in Tokyo.
Genotyping data and mRNA expression levels for Fas and FasL by genotypes were obtained from the HapMap phase II release 23 data from EBV-transformed lymphoblastoid cell lines from 270 individuals.
Two-side Student's t test within the stratum was used.
There were missing data for unavailable genotyping data.
Statistically significant results were in bold.