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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: J Mol Cell Cardiol. 2014 Jan;66:18–26. doi: 10.1016/j.yjmcc.2013.10.013

Figure 5. Ang II-induced Fat1 expression/activation via ERK1/2 phosphorylation.

Figure 5

ERK1/2 MAPK phosphorylation was evaluated in VSMCs stimulated with 1 μmol/L Ang II for short (A) and long (B) term in the absence or in the presence of apocynin (10 μmol/L). The effects of Ang II on Fat1 expression (C) and translocation to the cell membrane (D) were evaluated in the absence or in the presence of PD98059 (1 μmol/L). Representative immunoblots: ERK1/2 MAPK, ERK1/2 MAPK [Thr202/Tyr204], Fat1, β-actin. Results are mean ± SEM of 6 experiments. *P<0.05, vs vehicle.