Figure 6. Ang II induces VSMC migration through redox signaling and Fat1-dependent mechanisms.
VSMC migration in response to Ang II stimulation (1 μmol/L, 12 h) was determined using a Boyden chamber assay. Ang II-induced VSMC migration was determined in the absence or in the presence of apocynin (10 μmol/L), valsartan (10 μmol/L), PD98059 (1 μmol/L), and in cells transfected with siRNA for Nox1 or Fat1. Results are mean ± SEM of 4 experiments. *P<0.05, vs vehicle.