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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: J Mol Cell Cardiol. 2014 Jan;66:18–26. doi: 10.1016/j.yjmcc.2013.10.013

Figure 7. Signalling scheme linking Ang II and ROS generation to Fat1 and VSMC migration.

Figure 7

In VSMCs, Ang II induces activation of the AT1R, which triggers Nox1 activation and ROS generation; ROS activates ERK1/2 MAPK, leading to increased Fat1 cadherin activity and expression, which is required for Ang II-induced cellular migration.