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. Author manuscript; available in PMC: 2015 Feb 19.
Published in final edited form as: Neuron. 2014 Jan 23;81(4):873–887. doi: 10.1016/j.neuron.2013.12.011

Figure 1.

Figure 1

Trigeminal CCI-ION in Pirt-GCaMP3 mice shows long-lasting hyperalgesia from territories innervated by injured and uninjured nerves. (A) The CCI-ION and the anatomy in orofacial and trigeminal system are shown. (B) Mechanical hyperalgesia was tested at the ipsilateral V2 whisker pad (injured), the V3 lower jaw (uninjured), and contralateral V2 regions at 5, 14 and 28 days after CCI-ION (n=8) or sham (n=6) in mice. The data are expressed as an EF50 value and are presented as mean ± s.e.m. (C,D) Cheek injection of capsaicin evokes nocifensive facial wiping by the forepaw. The number of face wipes were measured within 30 minutes of capsaicin (0.5 μg) injection into the cheek (V2, injured) and the anterior part of ear skin (V3, uninjured; n=10 for each group). Data are presented as mean ± s.e.m. **p<0.01; ***p<0.001 vs. baseline (B), or sham (C,D).