Table 2. Association between metabolic syndrome (MetS) and its components and overall survival in old patients (age≧50 y) in a univariate and multivariate analysis.
Univariate analysis | Multivariate analysis | ||||
Factors | Number | Hazard ratio (95% confidence interval) | P value | Hazard ratio (95% confidence interval) | P value |
Gender (Male/Female) | 320/119 | 0.786(0.575–1.075) | 0.131 | ||
Tumor location(Proximal/Distal) | 266/173 | 0.638(0.480–0.847) | 0.002 | 0.634(0.476–0.845) | 0.002 |
Tumor size (≤5 cm/>5 cm) | 283/156 | 1.842(1.413–2.401) | <0.001 | 1.528(1.169–1.999) | 0.002 |
Degree of differentiation (not differentiated/Poorly differentiated, mucinous or signet ring adenocarcinoma/Moderate differentiated/Well differentiated) | 4/311/103/21 | 0.874(0.694–1.100) | 0.250 | ||
T stage(AJCC, 7th)(T1a/T1b/T2/T3/T4a/T4b) | 30/7/62/20/273/47 | 1.019(1.010–1.028) | <0.001 | 1.014(1.006–1.023) | 0.001 |
N stage(AJCC, 7th)(N0/N1/N2/N3a/N3b) | 162/67/103/78/29 | 1.037(1.027–1.046) | <0.001 | 1.035(1.025–1.045) | <0.001 |
Surgery type(radical/palliative) | 408/31 | 1.625(1.044–2.529) | 0.031 | 1.573(0.998–2.479) | 0.051 |
Angiolymphatic invasion(No/Yes) | 413/26 | 1.388(0.807–2.386) | 0.236 | ||
Chemotherapy (No/Yes) | 266/173 | 0.844(0.643–1.107) | 0.219 | ||
MetS (No/Yes) | 375/64 | 0.584(0.382–0.893) | 0.012 | 0.565(0.368–0.868) | 0.009 |
Number of MetS Components | 0.166 | ||||
0 | 115 | 1(Reference) | |||
1 | 152 | 1.007(0.720–1.408) | 0.969 | ||
2 | 108 | 1.074(0.749–1.538) | 0.698 | ||
3 | 50 | 0.630(0.380–1.046) | 0.074 | ||
4 | 14 | 0.476(0.173–1.321) | 0.151 | ||
Single component meeting the criteria of MetS | |||||
BMI (No/Yes) | 360/79 | 0.893(0.636–1.253) | 0.512 | ||
Fasting plasma glucose or diabetes (No/Yes) | 387/52 | 0.888(0.581–1.357) | 0.582 | ||
Blood pressure (No/Yes) | 244/195 | 0.862(0.660–1.125) | 0.274 | ||
Triglycerides (No/Yes) | 368/71 | 0.839(0.577–1.221) | 0.359 | ||
HDL (No/Yes) | 262/177 | 0.851(0.648–1.118) | 0.247 |
Abbreviations: AJCC: American Joint Committee on Cancer, MetS: metabolic syndrome, BMI: body mass index, HDL: high density lipoprotein.