Table 2. Association between metabolic syndrome (MetS) and its components and overall survival in old patients (age≧50 y) in a univariate and multivariate analysis.

		Univariate analysis		Multivariate analysis
Factors	Number	Hazard ratio (95% confidence interval)	P value	Hazard ratio (95% confidence interval)	P value
Gender (Male/Female)	320/119	0.786(0.575–1.075)	0.131
Tumor location(Proximal/Distal)	266/173	0.638(0.480–0.847)	0.002	0.634(0.476–0.845)	0.002
Tumor size (≤5 cm/>5 cm)	283/156	1.842(1.413–2.401)	<0.001	1.528(1.169–1.999)	0.002
Degree of differentiation (not differentiated/Poorly differentiated, mucinous or signet ring adenocarcinoma/Moderate differentiated/Well differentiated)	4/311/103/21	0.874(0.694–1.100)	0.250
T stage(AJCC, 7th)(T1a/T1b/T2/T3/T4a/T4b)	30/7/62/20/273/47	1.019(1.010–1.028)	<0.001	1.014(1.006–1.023)	0.001
N stage(AJCC, 7th)(N0/N1/N2/N3a/N3b)	162/67/103/78/29	1.037(1.027–1.046)	<0.001	1.035(1.025–1.045)	<0.001
Surgery type(radical/palliative)	408/31	1.625(1.044–2.529)	0.031	1.573(0.998–2.479)	0.051
Angiolymphatic invasion(No/Yes)	413/26	1.388(0.807–2.386)	0.236
Chemotherapy (No/Yes)	266/173	0.844(0.643–1.107)	0.219
MetS (No/Yes)	375/64	0.584(0.382–0.893)	0.012	0.565(0.368–0.868)	0.009
Number of MetS Components			0.166
0	115	1(Reference)
1	152	1.007(0.720–1.408)	0.969
2	108	1.074(0.749–1.538)	0.698
3	50	0.630(0.380–1.046)	0.074
4	14	0.476(0.173–1.321)	0.151
Single component meeting the criteria of MetS
BMI (No/Yes)	360/79	0.893(0.636–1.253)	0.512
Fasting plasma glucose or diabetes (No/Yes)	387/52	0.888(0.581–1.357)	0.582
Blood pressure (No/Yes)	244/195	0.862(0.660–1.125)	0.274
Triglycerides (No/Yes)	368/71	0.839(0.577–1.221)	0.359
HDL (No/Yes)	262/177	0.851(0.648–1.118)	0.247

Abbreviations: AJCC: American Joint Committee on Cancer, MetS: metabolic syndrome, BMI: body mass index, HDL: high density lipoprotein.