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. 2014 Mar 5;9(3):e89841. doi: 10.1371/journal.pone.0089841

Figure 4. Cisplatin and Doxycycline inhibit cell viability through Akt and ERK pathways in SKOV3 but not in SKOV3/DDP cells.

Figure 4

Reduction of Akt and ERK expression by Akt and ERK siRNA could attenuate the inhibitory effect on proliferation when treated with cisplatin and doxycycline for 48(C, D, G, H) but had no effect on proliferation in SKOV3/DDP cells (E, F, I, J) *, p<0.05; **, p<0.01.