Table 4.
Validation of published missplicing events in dystrophic muscle (t-test)
| Gene | Event | p-value (DM1 vs. N) | p-value (DM2 vs. N) | p-value (NMD vs. N)* |
|---|---|---|---|---|
| ANK2 | Exclusion exon 43a | 0.297000 | 6.91e-03 | nd |
| ATP2A1 | Exclusion exon 22 | 0.021100 | 2.68e-11 | 0.001050 |
| CAPZB | Exclusion exon 8a | 0.158000 | 6.05e-03 | nd |
| CLCN1 | Inclusion fetal exon | 0.011300 | 4.25e-03 | nd |
| FHOD1 | Exclusion exon 11a–12 | 0.007780 | 3.41e-10 | 0.510000 |
| LDB3 | Inclusion exon 4 | 0.064300 | 5.18e-06 | 0.526000 |
| LDB3 | Inclusion exon 7 | 0.000291 | 1.57e-06 | 0.316000 |
| MBNL1 | Inclusion exon 6a/7 | 0.004010 | 9.60e-06 | 0.044800 |
| MBNL2 | Inclusion exon 7 | 0.007990 | 3.38e-04 | 0.288000 |
| MEF2A | Inclusion exon 5a | 0.007620 | 2.73e-05 | 0.009280 |
| MEF2C | Inclusion exon 5a | 0.005230 | 1.59e-07 | 0.000883 |
| NRAP | Exclusion exon 12 | 0.953000 | 3.37e-03 | 0.017000 |
| PDLIM3 | Inclusion exon 5a | 0.047500 | 3.92e-04 | 0.859000 |
| RYR1 | Exclusion exon 70 | 0.251000 | 2.39e-02 | 0.528000 |
| TNNT2 | Inclusion exon 5 | 0.012200 | 5.99e-02 | 0.033700 |
| TNNT3 | Inclusion fetal exon | 0.077700 | 9.88e-05 | 0.439000 |
| TTN | Inclusion exon 11 | 0.009280 | 6.75e-04 | 0.000719 |
*
nd, not done.