Table 2. Common variant results.

			ARIC Study		CHS		FHS/MGH		Meta-analysis
SNP	Chr	Targeted region	β	SE	β	SE	β	SE	β	SE	OR	95% CI	P
Ten most significant associations across all 77 target gene regions
rs11265611	1	IL6R	–	–	–	–	−0.35	0.10	−0.35	0.10	0.70	0.58–0.85	1.7 × 10−6
rs855222	12	IGF1	–	–	0.38	0.13	–	–	0.38	0.13	1.45	1.15–1.88	2.1 × 10−4
rs114779117	5	MEF2C	0.77	0.65	0.70	0.39	0.90	0.39	0.80	0.25	2.22	1.35–3.64	6.3 × 10−4
rs10769256	11	SPI1	–	–	–	–	−0.29	0.10	−0.29	0.10	0.75	0.61–0.91	6.5 × 10−4
rs79435800	5	NIPAL4	0.18	0.33	0.47	0.28	0.36	0.26	0.35	0.17	1.42	1.03–1.97	7.0 × 10−4
rs72525420	20	JAG1	–	–	–	–	0.40	0.17	0.40	0.17	1.49	1.06–2.09	8.9 × 10−4
rs9805001	12	C12orf51	−1.59	0.87	−0.81	0.61	−0.98	0.76	−1.04	0.42	0.35	0.16–0.80	9.0 × 10−4
rs76416019	5	ADAM19	−0.00	0.31	0.40	0.27	0.30	0.26	0.25	0.16	1.29	0.94–1.77	9.7 × 10−4
rs72965937	2	IRS1	0.52	0.34	0.39	0.25	0.59	0.25	0.50	0.16	1.64	1.21–2.33	9.7 × 10−4
rs1520220	12	IGF1	0.36	0.16	0.19	0.14	0.22	0.13	0.25	0.08	1.28	1.09–1.51	1.3 × 10−3
Nominally significant SNPs within AF-related target regions
rs577676	1	PRRX1	−0.12	0.13	0.01	0.11	−0.38	0.11	−0.16	0.06	0.85	0.75–0.96	6.2 × 10−3
rs45498702	7	CAV1	–	–	−0.13	0.26	−0.72	0.26	−0.43	0.19	0.65	0.45–0.94	2.2 × 10−2
rs2213978	16	ZFHX3	−0.31	0.37	−0.35	0.32	−0.23	0.37	−0.30	0.20	0.74	0.50–1.10	2.7 × 10−2
rs576736	1	PRRX1	0.12	0.13	−0.01	0.11	0.29	0.12	0.13	0.07	1.14	1.00–1.31	4.4 × 10−2

AF = atrial fibrillation; ARIC = Atherosclerosis Risk in Communities; Chr = chromosome; CHS = Cardiovascular Health Study; CI = confidence interval; FHS = Framingham Heart Study; MGH = Massachusetts General Hospital; OR = odds ratio; SE = standard error; SNP = single-nucleotide polymorphism.