Table 2. Common variant results.
ARIC Study | CHS | FHS/MGH | Meta-analysis | ||||||||||
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SNP | Chr | Targeted region | β | SE | β | SE | β | SE | β | SE | OR | 95% CI | P |
Ten most significant associations across all 77 target gene regions | |||||||||||||
rs11265611 | 1 | IL6R | – | – | – | – | −0.35 | 0.10 | −0.35 | 0.10 | 0.70 | 0.58–0.85 | 1.7 × 10−6 |
rs855222 | 12 | IGF1 | – | – | 0.38 | 0.13 | – | – | 0.38 | 0.13 | 1.45 | 1.15–1.88 | 2.1 × 10−4 |
rs114779117 | 5 | MEF2C | 0.77 | 0.65 | 0.70 | 0.39 | 0.90 | 0.39 | 0.80 | 0.25 | 2.22 | 1.35–3.64 | 6.3 × 10−4 |
rs10769256 | 11 | SPI1 | – | – | – | – | −0.29 | 0.10 | −0.29 | 0.10 | 0.75 | 0.61–0.91 | 6.5 × 10−4 |
rs79435800 | 5 | NIPAL4 | 0.18 | 0.33 | 0.47 | 0.28 | 0.36 | 0.26 | 0.35 | 0.17 | 1.42 | 1.03–1.97 | 7.0 × 10−4 |
rs72525420 | 20 | JAG1 | – | – | – | – | 0.40 | 0.17 | 0.40 | 0.17 | 1.49 | 1.06–2.09 | 8.9 × 10−4 |
rs9805001 | 12 | C12orf51 | −1.59 | 0.87 | −0.81 | 0.61 | −0.98 | 0.76 | −1.04 | 0.42 | 0.35 | 0.16–0.80 | 9.0 × 10−4 |
rs76416019 | 5 | ADAM19 | −0.00 | 0.31 | 0.40 | 0.27 | 0.30 | 0.26 | 0.25 | 0.16 | 1.29 | 0.94–1.77 | 9.7 × 10−4 |
rs72965937 | 2 | IRS1 | 0.52 | 0.34 | 0.39 | 0.25 | 0.59 | 0.25 | 0.50 | 0.16 | 1.64 | 1.21–2.33 | 9.7 × 10−4 |
rs1520220 | 12 | IGF1 | 0.36 | 0.16 | 0.19 | 0.14 | 0.22 | 0.13 | 0.25 | 0.08 | 1.28 | 1.09–1.51 | 1.3 × 10−3 |
Nominally significant SNPs within AF-related target regions | |||||||||||||
rs577676 | 1 | PRRX1 | −0.12 | 0.13 | 0.01 | 0.11 | −0.38 | 0.11 | −0.16 | 0.06 | 0.85 | 0.75–0.96 | 6.2 × 10−3 |
rs45498702 | 7 | CAV1 | – | – | −0.13 | 0.26 | −0.72 | 0.26 | −0.43 | 0.19 | 0.65 | 0.45–0.94 | 2.2 × 10−2 |
rs2213978 | 16 | ZFHX3 | −0.31 | 0.37 | −0.35 | 0.32 | −0.23 | 0.37 | −0.30 | 0.20 | 0.74 | 0.50–1.10 | 2.7 × 10−2 |
rs576736 | 1 | PRRX1 | 0.12 | 0.13 | −0.01 | 0.11 | 0.29 | 0.12 | 0.13 | 0.07 | 1.14 | 1.00–1.31 | 4.4 × 10−2 |
AF = atrial fibrillation; ARIC = Atherosclerosis Risk in Communities; Chr = chromosome; CHS = Cardiovascular Health Study; CI = confidence interval; FHS = Framingham Heart Study; MGH = Massachusetts General Hospital; OR = odds ratio; SE = standard error; SNP = single-nucleotide polymorphism.