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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Free Radic Biol Med. 2013 Dec 25;68:315–325. doi: 10.1016/j.freeradbiomed.2013.12.018

Figure 1.

Figure 1

Body weight of B6 GPx1/2-DKO (DKO), GPx1/2-Nox1-TKO (TKO) and non-DKO mice from 10 to 50 days of age. Panel A. Body weight of male B6 littermates from 23 DKO, 18 TKO and 12 non-DKO mice having one WT GPx1 or GPx2 allele with either Nox1 genotype. DKO males are significantly lighter than TKOs starting at 22 days of age (12%; P=0.008) with temporary halt in growth at days 31–33. From 31 days on, DKO mice weighed 17–18% lower than TKO and non-DKO mice (P≤ 0.0006). Panel B. Body weight of female B6 littermates from 27 DKO, 25 het-TKO and 15 non-DKO mice. Female DKOs weighed the same as TKOs through 29 days of age, then significantly lighter through 50 days of age. At day 30, P=0.046; P<0.009, thereafter). The error bars are 1 standard deviation (SD).