Table 2.

Medical conditions associated with fungal and bacterial exposure during unusual indoor exposure

Organ system/pathway	Clinical effect	Exposure/agents
Upper airways: nose, sinuses, throat	Rhinitis, sinusitis, laryngitis	Fungi, allergens, irritants, MVOCs, particles
Lower airways: lung with bronchial system and alveoli	Bronchitis, asthma, bronchiolitis, allergic bronchopulmonary aspergillosis (ABPA), allergic extrinsic alveolitis (also known as hypersensitivity pneumonitis), toxic alveolitis, pneumonitis	Fungi, allergens, fungal by-products, fine particles
Combined upper and lower airway	Aspergillosis; fungal rhino-sinusitis	Fungi, fine particles, fungal irritants, allergens
Skin and mucous membranes	Urticaria, dermatitis (allergic or irritant type), conjunctivitis	Fungal irritants, allergens
Other organs: central nervous system, immune system, liver, kidney, endocrine system	Cognitive and psychiatric disorders; hepatitis, nephritis, thyroid, menses disorders (under investigation, anecdotal; commonly found in combination with other symptoms and disorders listed)	Fungi, organic dusts, microbial by-products, mycotoxins