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Generation of RMC in vitro from rodent BM cells or human PBMC. Mreg, DCreg and MDSC can be generated in vitro from precursors in rodent BM or human PBMC exposed to specific growth factors. In some cases, RMC (Mreg and MDSC) are also activated in vitro by the addition of inflammatory cytokines or other soluble factors. DCreg are often generated in the presence of anti-inflammatory cytokines or agents that suppress their activation into stimulatory DC.
