Figure 3.

Transcriptional Regulation of p16^INK4a. Expression of p16^INK4a requires the action of transcription factors that recruit and/or facilitate RNA polymerase association with the promoter (shown in green). Opposing this action are transcriptional repressors (shown in red). Direct interactions with the p16^INK4a promoter are depicted by a solid line, indirect interactions with a dotted line. The numbers below each binding site indicate the position of protein interaction relative to the p16^INK4a transcriptional start site. All locations correspond to the human genome unless designated by an ‘(m)’, which signifies the mouse genome. Proteins predicted to share a common binding site are depicted over top of one another.